Preface: proceedings of the 13th IASWS international conference

This short article forms the preface to the Proceedings of the 13th IASWS conference held in Grahamstown in July 2014. It provides a background to the conference, a synthesis of the 15 published papers published in the special issue of JSS and a poem - written and read by Harry Owen on the opening night of the conference

A review of assessment methods for river hydromorphology

The work leading to this paper has received funding for the EU’s FP7 under Grant Agreement No. 282656 (REFORM

The association between social capital and mental health and behavioural problems in children and adolescents: an integrative systematic review

Background Mental health is an important component of overall health and wellbeing and crucial for a happy and meaningful life. The prevalence of mental health problems amongst children and adolescent is high; with estimates suggesting 10-20% suffer from mental health problems at any given time. These mental health problems include internalising (e.g. depression and social anxiety) and externalising behavioural problems (e.g. aggression and anti-social behaviour). Although social capital has been shown to be associated with mental health/behavioural problems in young people, attempts to consolidate the evidence in the form of a review have been limited. This integrative systematic review identified and synthesised international research findings on the role and impact of family and community social capital on mental health/behavioural problems in children and adolescents to provide a consolidated evidence base to inform future research and policy development. Methods Nine electronic databases were searched for relevant studies and this was followed by hand searching. Identified literature was screened using review-specific inclusion/exclusion criteria, the data were extracted from the included studies and study quality was assessed. Heterogeneity in study design and outcomes precluded meta-analysis/meta-synthesis, the results are therefore presented in narrative form. Results After screening, 55 studies were retained. The majority were cross-sectional surveys and were conducted in North America (n = 33); seven were conducted in the UK. Samples ranged in size from 29 to 98,340. The synthesised results demonstrate that family and community social capital are associated with mental health/behavioural problems in children and adolescents. Positive parent–child relations, extended family support, social support networks, religiosity, neighbourhood and school quality appear to be particularly important. Conclusions To date, this is the most comprehensive review of the evidence on the relationships that exist between social capital and mental health/behavioural problems in children and adolescents. It suggests that social capital generated and mobilised at the family and community level can influence mental health/problem behaviour outcomes in young people. In addition, it highlights key gaps in knowledge where future research could further illuminate the mechanisms through which social capital works to influence health and wellbeing and thus inform policy development

Global urban environmental change drives adaptation in white clover.

Urbanization transforms environments in ways that alter biological evolution. We examined whether urban environmental change drives parallel evolution by sampling 110,019 white clover plants from 6169 populations in 160 cities globally. Plants were assayed for a Mendelian antiherbivore defense that also affects tolerance to abiotic stressors. Urban-rural gradients were associated with the evolution of clines in defense in 47% of cities throughout the world. Variation in the strength of clines was explained by environmental changes in drought stress and vegetation cover that varied among cities. Sequencing 2074 genomes from 26 cities revealed that the evolution of urban-rural clines was best explained by adaptive evolution, but the degree of parallel adaptation varied among cities. Our results demonstrate that urbanization leads to adaptation at a global scale

Stress-induced precocious aging in PD-patient iPSC-derived NSCs may underlie the pathophysiology of Parkinson's disease.

Parkinson's disease (PD) is an aging-related degenerative disorder arisen from the loss of dopaminergic neurons in substantia nigra. Although many genetic mutations have been implicated to be genetically linked to PD, the low incidence of familial PD carried with mutations suggests that there must be other factors such as oxidative stress, mitochondrial dysfunction, accumulation of misfolded proteins, and enhanced inflammation, which are contributable to the pathophysiology of PD. The major efforts of current research have been devoted to unravel the toxic effect of multiple factors, which directly cause the degeneration of dopaminergic neurons in adulthood. Until recently, several studies have demonstrated that NSCs had compromised proliferation and differentiation capacity in PD animal models or PD patient-derived iPS models, suggesting that the pathology of PD may be rooted in some cellular aberrations at early developmental stage but the mechanism remains to be elusive. Based on the early-onset PD patient-specific iPSCs, we found that PD-patient iPSC-derived NSCs were more susceptible to stress and became functionally compromised by radiation or oxidative insults. We further unraveled that stress-induced SIRT1 downregulation leading to autophagic dysfunction, which were responsible for these deficits in PD-NSCs. Mechanistically, we demonstrated that stress-induced activation of p38 MAPK suppressed SIRT1 expression, which in turn augmented the acetylation of multiple ATG proteins of autophagic complex and eventually led to autophagic deficits. Our studies suggest that early developmental deficits may, at least partially, contribute to the pathology of PD and provide a new avenue for developing better therapeutic interventions to PD

Present state and future perspectives of using pluripotent stem cells in toxicology research

The use of novel drugs and chemicals requires reliable data on their potential toxic effects on humans. Current test systems are mainly based on animals or in vitro–cultured animal-derived cells and do not or not sufficiently mirror the situation in humans. Therefore, in vitro models based on human pluripotent stem cells (hPSCs) have become an attractive alternative. The article summarizes the characteristics of pluripotent stem cells, including embryonic carcinoma and embryonic germ cells, and discusses the potential of pluripotent stem cells for safety pharmacology and toxicology. Special attention is directed to the potential application of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) for the assessment of developmental toxicology as well as cardio- and hepatotoxicology. With respect to embryotoxicology, recent achievements of the embryonic stem cell test (EST) are described and current limitations as well as prospects of embryotoxicity studies using pluripotent stem cells are discussed. Furthermore, recent efforts to establish hPSC-based cell models for testing cardio- and hepatotoxicity are presented. In this context, methods for differentiation and selection of cardiac and hepatic cells from hPSCs are summarized, requirements and implications with respect to the use of these cells in safety pharmacology and toxicology are presented, and future challenges and perspectives of using hPSCs are discussed

An annotated and critical glossary of the terminology of inclusion in healthcare and health research

yesThe importance of including members of the public has been accorded a significant position in health planning, service delivery and research. But this position masks a lack of clarity about terms that are used. This paper identifies terms that are in common use in the lexicon of community based involvement and engagement in health with the intention of clarifying meaning and thus reducing ambiguity. We define and distinguish between key terms related to inclusion, we consider the terminology attached to community processes and to the challenges of inclusion and we engage with the strengths and weaknesses of the commonly used metaphor of "a ladder of participation". We wish to contribute to the clear communication of intentions, challenges and achievements in pursuing varied forms of inclusion in health

The application of a hydraulic biotope matrix to the assessment of available habitat: Potential application to IFRs and river health monitoring

In an attempt to meet the requirement of the new South African Water law a number of initiatives are under way to determine the flow requirements for our rivers. An essential component of this initiative is the determination of the influence of changing flows on instream habitat. Two components need to be assessed: change in the aerial extent of habitat and change in habitat diversity. This paper presents a technique that aims to address qualitative and quantitative changes in instream habitat in response to changing flow discharge. A hydraulic biotope classification based on a matrix of substrate and flow type has been developed by the authors in collaboration with stream ecologists. Hydraulic biotope diversity was studied in the Buffalo River, Eastern Cape province, and results show how the composition of hydraulic biotopes depends on both the channel morphology and the discharge. These findings complement parallel studies carried out by Padmore and Newson in the United Kingdom. The classification system promises to provide a useful way to describe discharge-related changes in habitat. Early research by Wadeson and Rowntree was based on point surveys and ignored the spatial distribution and aerial extent of hydraulic biotopes. King and Schael have developed a mapping technique to describe the distribution of hydraulic biotopes, but its application is limited by time and manpower requirements. This paper demonstrates a relatively simple field technique, which is under development, based on overhead photography. The technique allows a quantitative assessment of the changes in the aerial distribution of hydraulic biotopes in response to changes in discharge. The potential application of this technique to both IFR assessments and the River Health Programme is discussed. Keywords: habitat mapping; environmental flows; geomorphology (Afr J Aqua Sci: 2001 26(1): 67-73

Design and implementation of a citizen technician–based suspended sediment monitoring network: Lessons from the Tsitsa River catchment, South Africa

Locally resident citizen technicians using basic equipment and Open Data Kit–enabled smartphones have collected flood-focused suspended sediment (SS) samples from 11 sites on the Tsitsa River and its tributaries, in the Eastern Cape Province of South Africa. In the highly degraded and gullied Tsitsa River catchment, existing modelled SS data were unverified and at odds with the results of studies based on dam sedimentation rates. Suspended sediment concentration (SSC), flux and yield data were required at subcatchment scale to support the prioritisation of community-based land rehabilitation initiatives in rural communal areas and to determine the relative contributions of subcatchments to SS yield at the site of the proposed Ntabelanga Dam. Approaches relying on researcher presence and/or installed instrumentation were precluded by cost, study area size, and the risk of equipment theft, vandalism and damage during high flows. Analysis of the quantitative data collected by the citizen technicians allows high-resolution SSC, flux, and yield data to be produced at subcatchment scale, which will be benchmarked by an acoustic SSC probe at a downstream Department of Water and Sanitation gauging weir. Qualitative descriptive and photographic data allows distant researchers to gain a real-time, catchment-wide overview of river and SS levels. This paper outlines the method, benefits and challenges of a direct-sampling approach that has the potential to address spatial and temporal challenges commonly experienced during SS sampling campaigns